Article
Mextli proteins use both canonical bipartite and novel tripartite binding modes to form eIF4E complexes that display differential sensitivity to 4E-BP regulation.
Genes & development - 1 Sept 2015
Peter Daniel, Weber Ramona, Köne Carolin, Chung Min-Yi, Ebertsch Linda, Truffault Vincent, Weichenrieder Oliver, Igreja Cátia, Izaurralde Elisa
Abstract excerpt
The eIF4E-binding proteins (4E-BPs) are a diverse class of translation regulators that share a canonical eIF4E-binding motif (4E-BM) with eIF4G. Consequently, they compete with eIF4G for binding to eIF4E, thereby inhibiting translation initiation. Mextli (Mxt) is an unusual 4E-BP that promotes translation by also interacting with eIF3. Here we present the crystal structures of the eIF4E-binding regions of the...
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