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Article

An Intracellular Amyloid-β/AβPP Epitope Correlates with Neurodegeneration in those Neuronal Populations Early Involved in Alzheimer's Disease.

Journal of Alzheimer's disease : JAD - 1 Jan 2017

Esquerda-Canals Gisela, Martí-Clúa Joaquim, Roda Alejandro R, Villegas Sandra

Abstract excerpt

The main histopathological hallmarks of Alzheimer's disease (AD) are the extracellular deposition of neuritic amyloid plaques, composed of amyloid-β (Aβ) peptide, and the intracellular accumulation of neurofibrillary tangles, composed of hyperphosphorylated tau. Both traits are emulated in the 3xTg-AD mouse model. Because the relevance of this model in the bibliography and the main role of Aβ in neuronal...

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PMID: 28697564
DOI: 10.3233/JAD-170218

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