Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Accumulation of murine amyloid-β mimics early Alzheimer’s disease

18 May 2015

Abstract excerpt

Amyloidosis mouse models of Alzheimer's disease are generally established by transgenic approaches leading to an overexpression of mutated human genes that are known to be involved in the generation of amyloid-β in Alzheimer's families. Although these models made substantial contributions to the current knowledge about the 'amyloid hypothesis' of Alzheimer's disease, the overproduction of amyloid-β peptides...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Drug Transport and Resistance Mechanisms
Share to Trace Elements in Health

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25991605
DOI: 10.1093/brain/awv137

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Accumulation of murine amyloid-β mimics early Alzheimer’s diseasePMID 25991605Read ↗

Knock-in of human BACE1 cleaves murine APP and reiterates Alzheimer-like phenotypes.Semantic proximity Read ↗

Neprilysin Deficiency Alters the Neuropathological and Behavioral Phenotype in the 5XFAD Mouse Model of Alzheimer's DiseaseSemantic proximity Read ↗

Characterization of an 'Amyloid Only' Transgenic (B6C3-Tg(APPswe,PSEN1dE9)85Dbo/Mmjax) Mouse Model of Alzheimer's Disease.Semantic proximity Read ↗

Transmissible long-term neuroprotective and pro-cognitive effects of 1-42 beta-amyloid with A2T icelandic mutation in an Alzheimer's disease mouse model.Semantic proximity Read ↗

Alzheimer disease models and human neuropathology: similarities and differencesSemantic proximity Read ↗

BACE1 (beta-secretase) transgenic and knockout mice: identification of neurochemical deficits and behavioral changes.Semantic proximity Read ↗

Early-onset and robust amyloid pathology in a new homozygous mouse model of Alzheimer's disease.Semantic proximity Read ↗

Intraneuronal accumulation of C99 contributes to synaptic alterations, apathy-like behavior, and spatial learning deficits in 3×TgAD and 2×TgAD mice.Semantic proximity Read ↗

A case for a non‐transgenic animal model of Alzheimer's diseaseSemantic proximity Read ↗

Animal models of amyloid‐β‐related pathologies in Alzheimer’s diseaseSemantic proximity Read ↗

An Intracellular Amyloid-β/AβPP Epitope Correlates with Neurodegeneration in those Neuronal Populations Early Involved in Alzheimer's Disease.Semantic proximity Read ↗

Cognitive deficits in single App knock-in mouse modelsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.