Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hippocampal GABAergic neurons are susceptible to amyloid-β toxicity in vitro and are decreased in number in the Alzheimer's disease TgCRND8 mouse model.

Journal of Alzheimer's disease : JAD - 1 Jan 2012

Krantic Slavica, Isorce Nathalie, Mechawar Naguib, Davoli Maria Antonietta, Vignault Erika, Albuquerque Marilia, Chabot Jean-Guy, Moyse Emmanuel, Chauvin Jean-Pierre, Aubert Isabelle, McLaurin Joanne, Quirion Rémi

Abstract excerpt

The relevance of γ-amino-butyric acid (GABA)-ergic dysfunctions in the pathology of Alzheimer's disease (AD) remains a matter of debate. In the present study, we characterized the toxicity of amyloid-β (Aβ) on hippocampal GABAergic neurons both in vivo and in vitro. In the TgCRND8 mouse model of AD, we found a significant decrease in the number of hippocampal neurons immunoreactive for glutamate decarboxylase 67...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyloid beta-Peptides
Share to Cell Death

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to GABAergic Neurons

Share to Glutamate Decarboxylase

Share to Hippocampus

Share to Phosphopyruvate Hydratase

Share to Presenilin-1

Share to Rats, Wistar

Source

Identifiers

PMID: 22232004
DOI: 10.3233/JAD-2011-110830

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hippocampal GABAergic neurons are susceptible to amyloid-β toxicity in vitro and are decreased in number in the Alzheimer's disease TgCRND8 mouse model.PMID 22232004Read ↗

Gad67 haploinsufficiency reduces amyloid pathology and rescues olfactory memory deficits in a mouse model of Alzheimer’s diseaseSemantic proximity Read ↗

Mutation-induced loss of APP function causes GABAergic depletion in recessive familial Alzheimer's disease: analysis of Osaka mutation-knockin mice.Semantic proximity Read ↗

A bell-shaped dependence between amyloidosis and GABA accumulation in astrocytes in a mouse model of Alzheimer's disease.Semantic proximity Read ↗

An Intracellular Amyloid-β/AβPP Epitope Correlates with Neurodegeneration in those Neuronal Populations Early Involved in Alzheimer's Disease.Semantic proximity Read ↗

Astrocyte-Specific Phenotyping of FAD4T as an Alzheimer's Disease Mouse Model.Semantic proximity Read ↗

Excitoprotective effects of conditional tau reduction in excitatory neurons and in adulthoodSemantic proximity Read ↗

Region- and age-specific changes in glutamate transport in the AβPP23 mouse model for Alzheimer's disease.Semantic proximity Read ↗

ApoE4 induces Aβ42, tau, and neuronal pathology in the hippocampus of young targeted replacement apoE4 mice.Semantic proximity Read ↗

Early neuronal loss and axonal/presynaptic damage is associated with accelerated amyloid-β accumulation in AβPP/PS1 Alzheimer's disease mice subiculum.Semantic proximity Read ↗

Imbalance between GABAergic and Glutamatergic Transmission Impairs Adult Neurogenesis in an Animal Model of Alzheimer's DiseaseSemantic proximity Read ↗

Age-dependent loss of dentate gyrus granule cells in APP/PS1KI mice.Semantic proximity Read ↗

Alzheimer disease-like cellular phenotype of newborn granule neurons can be reversed in GSK-3β-overexpressing mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.