Article

Intracellular Amyloid-β in the Normal Rat Brain and Human Subjects

2023-02-15

Abstract excerpt

Amyloid-beta (Aβ) is a normal product of neuronal activity, and the two most common variants are 40 or 42 residues long. Of these, the 42 residue-version (Aβ42) is normally less abundant but more prone to self-aggregate, and is thought to cause Alzheimer’s disease (AD). Much knowledge about AD-pathogenesis comes from the study of rodents made to model aspects of the disease by expressing AD-relevant human transgen...

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Literature Corpus work: cf3b010f-d070-5c64-a81c-ae4c2f57ae3f
DOI: 10.1101/2023.02.15.528693

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