Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Intraneuronal beta-amyloid accumulation in the amygdala enhances fear and anxiety in Alzheimer's disease transgenic mice.

Biological psychiatry - 15 Mar 2010

España Judit, Giménez-Llort Lydia, Valero Jorge, Miñano Alfredo, Rábano Alberto, Rodriguez-Alvarez José, LaFerla Frank M, Saura Carlos A

Abstract excerpt

BACKGROUND: Alzheimer's disease (AD) is characterized by progressive memory decline and neuropsychiatric symptoms. Despite common emotional symptoms in AD such as anxiety and fear are associated with a more rapid cognitive decline, the pathological mechanisms involved in these behavioral changes...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amygdala
Share to Anxiety
Share to Conditioning, Classical

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Extracellular Signal-Regulated MAP Kinases

Share to Memory Disorders

Share to Polycomb-Group Proteins

Share to Valproic Acid

Source

Identifiers

PMID: 19664757
DOI: 10.1016/j.biopsych.2009.06.015

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19664757-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Intraneuronal beta-amyloid accumulation in the amygdala enhances fear and anxiety in Alzheimer's disease transgenic mice.PMID 19664757Read ↗

Differential neural circuit vulnerability to β-amyloid and tau pathologies in novel Alzheimer’s disease miceSemantic proximity Read ↗

Cognitive and emotional alterations in App knock-in mouse models of Aβ amyloidosisSemantic proximity Read ↗

Overexpression of wild-type human APP in mice causes cognitive deficits and pathological features unrelated to Abeta levels.Semantic proximity Read ↗

Early Long-Term Memory Impairment and Changes in the Expression of Synaptic Plasticity-Associated Genes, in the McGill-R-Thy1-APP Rat Model of Alzheimer's-Like Brain AmyloidosisSemantic proximity Read ↗

Severe amygdala dysfunction in a MAPT transgenic mouse model of frontotemporal dementia.Semantic proximity Read ↗

Glial and BBB modifications correlate with early anxio-depressive-like behaviors and cognitive inflexibility in 3xTg-AD miceSemantic proximity Read ↗

An Intracellular Amyloid-β/AβPP Epitope Correlates with Neurodegeneration in those Neuronal Populations Early Involved in Alzheimer's Disease.Semantic proximity Read ↗

β-Amyloid pathology alters neural network activation during retrieval of contextual fear memories in a mouse model of Alzheimer's disease.Semantic proximity Read ↗

Tau Protein Mediates APP Intracellular Domain (AICD)-Induced Alzheimer's-Like Pathological Features in Mice.Semantic proximity Read ↗

Progressive cognitive impairment and anxiety induction in the absence of plaque deposition in C57BL/6 inbred mice expressing transgenic amyloid precursor protein.Semantic proximity Read ↗

Insoluble Aβ overexpression in an <i>App</i> knock-in mouse model alters microstructure and gamma oscillations in the prefrontal cortex, and social and anxiety-related behavioursSemantic proximity Read ↗

Environmental enrichment eliminates the anxiety phenotypes in a triple transgenic mouse model of Alzheimer's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.