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Article

Intraneuronal beta-amyloid accumulation in the amygdala enhances fear and anxiety in Alzheimer's disease transgenic mice.

Biological psychiatry - 15 Mar 2010

España Judit, Giménez-Llort Lydia, Valero Jorge, Miñano Alfredo, Rábano Alberto, Rodriguez-Alvarez José, LaFerla Frank M, Saura Carlos A

Abstract excerpt

BACKGROUND: Alzheimer's disease (AD) is characterized by progressive memory decline and neuropsychiatric symptoms. Despite common emotional symptoms in AD such as anxiety and fear are associated with a more rapid cognitive decline, the pathological mechanisms involved in these behavioral changes remain largely elusive. In this study, we examined the pathological mechanisms of emotional behavior in...

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Source

Identifiers

PMID: 19664757
DOI: 10.1016/j.biopsych.2009.06.015

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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