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Article

Regulated Polarization of Tumor-Associated Macrophages by miR-145 via Colorectal Cancer-Derived Extracellular Vesicles.

Journal of immunology (Baltimore, Md. : 1950) - 15 Aug 2017

Shinohara Haruka, Kuranaga Yuki, Kumazaki Minami, Sugito Nobuhiko, Yoshikawa Yuki, Takai Tomoaki, Taniguchi Kohei, Ito Yuko, Akao Yukihiro

Abstract excerpt

Macrophages are polarized into functional classically activated and alternatively activated (M2) phenotypes depending on their microenvironment, and these cells play an important role in the immune system. M2-like polarization of tumor-associated macrophages (TAMs) is activated by various secretions from cancer cells; however, the interaction between cancer cells and TAMs is not well understood. Recent studies...

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PMID: 28696255
DOI: 10.4049/jimmunol.1700167

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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