Article
Programming Cell-Derived Vesicles with Enhanced Immunomodulatory Properties.
Advanced healthcare materials - 1 Oct 2023
Neupane Khaga R, Ramon Geraldine S, Harvey Brock, Chun Byeong, Aryal Surya P, Masud Abdullah A, McCorkle J Robert, Kolesar Jill M, Kekenes-Huskey Peter M, Richards Christopher I
Abstract excerpt
Tumor-associated macrophages are the predominant immune cells present in the tumor microenvironment and mostly exhibit a pro-tumoral M2-like phenotype. However, macrophage biology is reversible allowing them to acquire an anti-tumoral M1-like phenotype in response to external stimuli. A potential therapeutic strategy for treating cancer may be achieved by modulating macrophages from an M2 to an M1-like phenotype...
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