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Pancreatic cancer-derived exosomal miR-510 promotes macrophage M2 polarization and facilitates cancer cell aggressive phenotypes.

Human cell - 12 Nov 2024

Wang Tao, Ye Lin, Zhou Yingjie, Zhang Xionghan, Li Renjian, Zhou Yi, Weng Jun, Mo Qingrong, Yu Yaqun

Abstract excerpt

Extensive tumor microenvironment (TME) and tumor-associated macrophages (TAMs) contribute to the initiation and progression of pancreatic cancer (PC). Cancer cell-derived exosomal miRNAs that stimulate macrophage M2 polarization might play an important role in the process. In the current study, we observed significant upregulation of miR-510 in PC cell lines in comparison to normal HPDE cell line, with PANC-1...

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PMID: 39528705
DOI: 10.1007/s13577-024-01144-0

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