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Article

Role of colorectal cancer-derived exosomes in modulating macrophage phenotype during tumor development.

Carcinogenesis - 26 Dec 2025

Wadhonkar Khandu, Das Dhruv, Kant Chittela Rajani, Obukhov Alexander G, Baig Mirza S

Abstract excerpt

Colorectal cancer (CRC) is one of the deadliest malignancies and is characterized by a complex tumor microenvironment (TME) comprising cancer and immune cells engaged in extensive signaling crosstalk. The composition of the TME changes with disease stage and contributes to tumor aggressiveness and resistance to therapy. Although tumor associated immune cells are known to promote cancer progression, the mechanisms...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 41554687
DOI: 10.1093/carcin/bgag003

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