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Article

Tumor-associated macrophage-specific CD155 contributes to M2-phenotype transition, immunosuppression, and tumor progression in colorectal cancer.

Journal for immunotherapy of cancer - 1 Sept 2022

Zhu Xudong, Liang Rongpu, Lan Tianyun, Ding Dongbing, Huang Shengxin, Shao Jun, Zheng Zongheng, Chen Tufeng, Huang Yong, Liu Jianpei, Pathak Janak L, Wei Hongbo, Wei Bo

Abstract excerpt

BACKGROUND: Onco-immunogenic molecule CD155 is overexpressed in various tumor microenvironments (TME) including in colorectal cancer (CRC). Tumor-associated macrophages (TAMs) are the most abundant immune cells in CRC TME and play a vital role in CRC progression and metastasis. Most studies have focused on investigating the role of CRC cell-specific CD155 on CRC progression, while the contribution of...

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Identifiers

PMID: 36104099
DOI: 10.1136/jitc-2021-004219
PMCID: PMC9476138

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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