Article

Tumor extracellular vesicles are required for tumor-associated macrophage programming

2018-07-23

Abstract excerpt

<h4>Summary</h4> Triple-negative breast cancers (TNBC) are highly infiltrated by tumor-associated macrophages (TAMs) that promote tumor growth, survival, metastasis and therapeutic resistance. Although cytokines such as CCL5 have been implicated in TAM recruitment to TNBC tumors, the mechanism by which tumor cells educate TAMs is not understood. Here we show that tumor EVs are both necessary and sufficient for pr...

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Literature Corpus work: 1efe15ba-06be-51e2-ad97-13367327c1d7
DOI: 10.1101/375022

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