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Ovarian Cancer Cell-Derived Exosomal miR-205 Promotes M2 Macrophage Polarization and Ovarian Cancer Cell Metastasis By Activating The AKT/mTOR Signalling Pathway

2021-04-06

Abstract excerpt

<h4>Background: </h4> Tumour-associated macrophages (TAMs) are the most abundant immune cells in the tumour environment and are considered to be similar to M2 macrophages, which facilitate cancer progression. Exosomes, as important mediators of cell-to-cell communication, can alter the phenotype of TAMs by transferring microRNAs (miRNAs) that influence targets and signalling pathways. However, the exact mechanisms...

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Literature Corpus work: 00f224f9-b23c-5d8d-bcd4-9ad142b83d67
DOI: 10.21203/rs.3.rs-373729/v1

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