Article

Optogenetic Clustering of Human IRE1 Reveals Differential Regulation of Transcription and mRNA Splice Isoform Abundance by the UPR

2025-07-21

Abstract excerpt

Inositol-requiring enzyme 1 (IRE1) is one of three known sensor proteins that respond to homeostatic perturbations in the metazoan endoplasmic reticulum. The three sensors collectively initiate an intertwined signaling network called the Unfolded Protein Response (UPR). Although IRE1 plays pivotal roles in human health and development, understanding its specific contributions to the UPR remains a challenge due to...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: df4b377c-c628-5c29-a529-afacbf47f255
DOI: 10.1101/2025.07.16.665212

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Optogenetic Clustering of Human IRE1 Reveals Differential Regulation of Transcription and mRNA Splice Isoform Abundance by the UPRDOI 10.1101/2025.07.16.665212Read

The UPRosome – decoding novel biological outputs of IRE1α functionSemantic proximity Read

A topology-dependent IRE1α signaling axis generates a cryptic XBP1 isoform present in human cancersSemantic proximity Read

How IRE1 Reacts to ER StressSemantic proximity Read

Involvement of the IRE1α-XBP1 Pathway and XBP1s-Dependent Transcriptional Reprogramming in Metabolic DiseasesSemantic proximity Read

Phosphorylation at Ser724 of the ER stress sensor IRE1α governs its activation state and limits ER stress-induced hepatosteatosis.Semantic proximity Read

Genomic targets of the IRE1-XBP1s pathway in mediating metabolic adaptation in epithelial plasticitySemantic proximity Read

ER stress sensor Ire1 deploys a divergent transcriptional program in response to lipid bilayer stressSemantic proximity Read

QRICH1 dictates the outcome of ER stress through transcriptional control of proteostasisSemantic proximity Read

Endoplasmic reticulum stress signaling: the microRNA connectionSemantic proximity Read

Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response.Semantic proximity Read

A Human Genome-Wide RNAi Screen Reveals Diverse Modulators that Mediate IRE1α–XBP1 ActivationSemantic proximity Read

Disruption of proteostasis causes IRE1 mediated reprogramming of alveolar epithelial cellsSemantic proximity Read