Article
mTOR/Raptor signaling is critical for skeletogenesis in mice through the regulation of Runx2 expression.
Cell death and differentiation - 1 Nov 2017
Dai Qinggang, Xu Zhan, Ma Xuhui, Niu Ningning, Zhou Siru, Xie Furong, Jiang Lingyong, Wang Jun, Zou Weiguo
Abstract excerpt
The mammalian target of rapamycin (mTOR)/regulatory-associated protein of mTOR (Raptor) pathway transmits and integrates different signals including growth factors, nutrients, and energy metabolism. Nearly all these signals have been found to play roles in skeletal biology. However, the contribution of mTOR/Raptor to osteoblast biology in vivo remains to be elucidated as the conclusions of recent studies are...
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