Article
mTORC1 Plays an Important Role in Skeletal Development by Controlling Preosteoblast Differentiation.
Molecular and cellular biology - 1 Apr 2017
Fitter Stephen, Matthews Mary P, Martin Sally K, Xie Jianling, Ooi Soo Siang, Walkley Carl R, Codrington John D, Ruegg Markus A, Hall Michael N, Proud Christopher G, Gronthos Stan, Zannettino Andrew C W
Abstract excerpt
The mammalian target of rapamycin complex 1 (mTORC1) is activated by extracellular factors that control bone accrual. However, the direct role of this complex in osteoblast biology remains to be determined. To investigate this question, we disrupted mTORC1 function in preosteoblasts by targeted deletion of Raptor (Rptor) in Osterix-expressing cells. Deletion of Rptor resulted in reduced limb length that was...
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