Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Runx2 Regulates Endochondral Ossification Through Control of Chondrocyte Proliferation and Differentiation

24 May 2014

Abstract excerpt

Synthesis of cartilage by chondrocytes is an obligatory step for endochondral ossification. Global deletion of the Runx2 gene results in complete failure of the ossification process, but the underlying cellular and molecular mechanisms are not fully known. Here, we elucidated Runx2 regulatory control distinctive to chondrocyte and cartilage tissue by generating Runx2 exon 8 floxed mice. Deletion of Runx2 gene in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Metabolism and Diseases
Share to Inflammatory mediators and NSAID effects
Share to Osteoarthritis Treatment and Mechanisms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24862038
DOI: 10.1002/jbmr.2287

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Runx2 Regulates Endochondral Ossification Through Control of Chondrocyte Proliferation and DifferentiationPMID 24862038Read ↗

Microarray analysis on Runx2-deficient mouse embryos reveals novel Runx2 functions and target genes during intramembranous and endochondral bone formation.Semantic proximity Read ↗

Runx2, a multifunctional transcription factor in skeletal development.Semantic proximity Read ↗

Overlapping expression of Runx1(Cbfa2) and Runx2(Cbfa1) transcription factors supports cooperative induction of skeletal developmentSemantic proximity Read ↗

The roles of Runx1 in skeletal development and osteoarthritis: A concise reviewSemantic proximity Read ↗

Role of Runx genes in chondrocyte differentiation.Semantic proximity Read ↗

Deletion of Runx2 in condylar chondrocytes disrupts TMJ tissue homeostasisSemantic proximity Read ↗

Runx1 up-regulates chondrocyte to osteoblast lineage commitment and promotes bone formation by enhancing both chondrogenesis and osteogenesisSemantic proximity Read ↗

Runx3 regulates chondrocyte phenotype by controlling multiple genes involved in chondrocyte proliferation and differentiation.Semantic proximity Read ↗

Functional impact of pathogenic Runt domain mutations in <i>Runx2</i> on skeletal and dental development in cleidocranial dysplasiaSemantic proximity Read ↗

Emerging RUNX2-Mediated Gene Regulatory Mechanisms Consisting of Multi-Layered Regulatory Networks in Skeletal DevelopmentSemantic proximity Read ↗

Targeting Runx2 expression in hypertrophic chondrocytes impairs endochondral ossification during early skeletal developmentSemantic proximity Read ↗

Runx1 dose-dependently regulates endochondral ossification during skeletal development and fracture healing.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.