Runx2, a multifunctional transcription factor in skeletal development.

Abstract excerpt

The identification of Runx2 (runt-related protein 2) function has greatly advanced the understanding of skeletal development over the last 5 years. Runx2 is regulated transcriptionally and post-translationally through the activity of many identified factors, although, the physiological significance of each remains to be demonstrated. The interaction of Runx2 with other transcription factors and cofactors has been...

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