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Article

BMP and mTOR signaling in heterotopic ossification: Does their crosstalk provide therapeutic opportunities?

15 Apr 2019

Abstract excerpt

Heterotopic ossification (HO) refers to the pathological formation of ectopic bone in soft tissues, it occurs following severe trauma or in patients with a rare genetic disorder known as fibrodysplasia ossificans progressiva. The pathological process of HO formation is a two-step mechanism: inflammation and destruction of connective tissues, followed by bone formation. The latter is further subdivided into three...

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PMID: 30989716
DOI: 10.1002/jcb.28710

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