Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

mTORC1 Signaling Promotes Osteoblast Differentiation from Preosteoblasts

19 Jun 2015

Abstract excerpt

Preosteoblasts are precursor cells that are committed to the osteoblast lineage. Differentiation of these cells to mature osteoblasts is regulated by the extracellular factors and environmental cues. Recent studies have implicated mTOR signaling in the regulation of osteoblast differentiation. However, mTOR exists in two distinct protein complexes (mTORC1 and mTORC2), and the specific role of mTORC1 in regulating...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone health and treatments
Share to Bone Metabolism and Diseases
Share to PI3K/AKT/mTOR signaling in cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26090674
DOI: 10.1371/journal.pone.0130627

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

mTORC1 Signaling Promotes Osteoblast Differentiation from PreosteoblastsPMID 26090674Read ↗

mTORC1 Plays an Important Role in Skeletal Development by Controlling Preosteoblast Differentiation.Semantic proximity Read ↗

mTOR/Raptor signaling is critical for skeletogenesis in mice through the regulation of Runx2 expression.Semantic proximity Read ↗

Targeting the mTOR-Autophagy Axis: Unveiling Therapeutic Potentials in OsteoporosisSemantic proximity Read ↗

mTORC2 Signaling Promotes Skeletal Growth and Bone Formation in MiceSemantic proximity Read ↗

Rap1A Regulates Osteoblastic Differentiation via the ERK and p38 Mediated SignalingSemantic proximity Read ↗

Defective autophagy in osteoblasts induces endoplasmic reticulum stress and causes remarkable bone loss.Semantic proximity Read ↗

Zebrafish raptor mutation inhibits the activity of mTORC1, inducing craniofacial defects due to autophagy-induced neural crest cell death.Semantic proximity Read ↗

PINK1 deficiency impairs osteoblast differentiation through aberrant mitochondrial homeostasisSemantic proximity Read ↗

Autophagy in bone homeostasis and the onset of osteoporosisSemantic proximity Read ↗

Signaling pathways governing osteoblast proliferation, differentiation and function.Semantic proximity Read ↗

mTOR inhibition rescues osteopenia in mice with systemic sclerosisSemantic proximity Read ↗

BMP and mTOR signaling in heterotopic ossification: Does their crosstalk provide therapeutic opportunities?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.