Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Runx2 Regulates G Protein-coupled Signaling Pathways to Control Growth of Osteoblast Progenitors

15 Jul 2008

Abstract excerpt

Runt-related transcription factor 2 (Runx2) controls lineage commitment, proliferation, and anabolic functions of osteoblasts as the subnuclear effector of multiple signaling axes (e.g. transforming growth factor-beta/BMP-SMAD, SRC/YES-YAP, and GROUCHO/TLE). Runx2 levels oscillate during the osteoblast cell cycle with maximal levels in G(1). Here we examined what functions and target genes of Runx2 control...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Metabolism and Diseases
Share to Cytokine Signaling Pathways and Interactions
Share to TGF-β signaling in diseases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18625716
DOI: 10.1074/jbc.m802453200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Runx2 Regulates G Protein-coupled Signaling Pathways to Control Growth of Osteoblast ProgenitorsPMID 18625716Read ↗

Runx2 Regulates Endochondral Ossification Through Control of Chondrocyte Proliferation and DifferentiationSemantic proximity Read ↗

Role and regulation of RUNX2 in osteogenesisSemantic proximity Read ↗

Runx2 Protein Expression Utilizes the Runx2 P1 Promoter to Establish Osteoprogenitor Cell Number for Normal Bone FormationSemantic proximity Read ↗

Runx2, a multifunctional transcription factor in skeletal development.Semantic proximity Read ↗

The Bone-specific Expression of Runx2 Oscillates during the Cell Cycle to Support a G1-related Antiproliferative Function in OsteoblastsSemantic proximity Read ↗

Regulatory Controls for Osteoblast Growth and Differentiation: Role of Runx/Cbfa/AML FactorsSemantic proximity Read ↗

Runx2 expression and action in chondrocytes are regulated by retinoid signaling and parathyroid hormone-related peptide (PTHrP)Semantic proximity Read ↗

LGR6 is necessary for attaining peak bone mass and regulates osteogenesis through differential ligand useSemantic proximity Read ↗

Runt-related transcription factor-2 (Runx2) is required for bone matrix protein gene expression in committed osteoblasts in miceSemantic proximity Read ↗

Structural coupling of Smad and Runx2 for execution of the BMP2 osteogenic signal.Semantic proximity Read ↗

mTOR/Raptor signaling is critical for skeletogenesis in mice through the regulation of Runx2 expression.Semantic proximity Read ↗

Runx2: A master organizer of gene transcription in developing and maturing osteoblastsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.