Article
Translational Control of Sox9 RNA by mTORC1 Contributes to Skeletogenesis.
Stem cell reports - 10 Jul 2018
Iezaki Takashi, Horie Tetsuhiro, Fukasawa Kazuya, Kitabatake Makoto, Nakamura Yuka, Park Gyujin, Onishi Yuki, Ozaki Kakeru, Kanayama Takashi, Hiraiwa Manami, Kitaguchi Yuka, Kaneda Katsuyuki, Manabe Takayuki, Ishigaki Yasuhito, Ohno Mutsuhito, Hinoi Eiichi
Abstract excerpt
The mechanistic/mammalian target of rapamycin complex 1 (mTORC1) regulates cellular function in various cell types. Although the role of mTORC1 in skeletogenesis has been investigated previously, here we show a critical role of mTORC1/4E-BPs/SOX9 axis in regulating skeletogenesis through its expression in undifferentiated mesenchymal cells. Inactivation of Raptor, a component of mTORC1, in limb buds before...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.