Article
Opposite effects of β2-adrenoceptor gene deletion on insulin signaling in liver and skeletal muscle.
Nutrition, metabolism, and cardiovascular diseases : NMCD - 1 Jul 2017
Cipolletta E, Del Giudice C, Santulli G, Trimarco B, Iaccarino G
Abstract excerpt
BACKGROUND AND AIM: β2-Adrenoceptors (β2-ARs) are G protein-coupled receptors (GPCRs) expressed in the major insulin target tissues. The interplay between β2-AR and insulin pathways is involved in the maintenance of glucose homeostasis. The aim of this study was to explore the consequences of β2-ARs deletion on insulin sensitivity and insulin signaling cascade in metabolically active tissues. METHODS AND RESULTS:...
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