Article

Impairment of the IR-IRS-PI3K-AKT signaling pathway in Insulin Resistance: New Insights into Insulin Resistance Mechanisms

2025-09-12

Abstract excerpt

Insulin is a master metabolic hormone that regulates the metabolism of glucose and fat. Obesity produces factors that increase insulin resistance, which is the leading cause of type 2 diabetes in the world. In insulin resistance, the main signaling pathway IR-IRS-PI3K-AKT pathway, is disrupted, which is the central cause of insulin resistance and T2DM. This review explains the molecular mechanism of the dysfunctio...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 51900d5b-206b-58a9-9547-45424905d326
DOI: 10.22541/au.175767205.55981786/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Impairment of the IR-IRS-PI3K-AKT signaling pathway in Insulin Resistance: New Insights into Insulin Resistance MechanismsDOI 10.22541/au.175767205.55981786/v1Read

Unraveling The Mystery of Insulin Resistance: From Principle Mechanistic Insights and Consequences to Therapeutic InterventionsSemantic proximity Read

Insulin receptor signaling in normal and insulin-resistant states.Semantic proximity Read

Molecular biology of insulin resistance.Semantic proximity Read

Insulin resistance uncoupled from dyslipidemia due to C-terminal PIK3R1 mutations.Semantic proximity Read

Regulating insulin signaling and β-cell function through IRS proteinsThis paper is one of a selection of papers published in this Special Issue, entitled Second Messengers and Phosphoproteins—12th International Conference.Semantic proximity Read

PI3K-C2α Knockdown Results in Rerouting of Insulin Signaling and Pancreatic Beta Cell ProliferationSemantic proximity Read

[Insulin receptors, mechanism of signal transduction. Examples of abnormalities in states of insulin resistance].Semantic proximity Read

Genetic Variants Affecting Insulin Signaling Pathways and Risk of Diabetes: A Comprehensive Systematic ReviewSemantic proximity Read

Molecular mechanisms of inherited insulin resistance.Semantic proximity Read

The association of PTEN/PI3K/Akt pathway gene expression with insulin indices in adipose tissues of non-diabetic female adults: a cross-sectional studySemantic proximity Read

[Insulin resistance and molecular abnormalities of the insulin receptor in type II diabetes].Semantic proximity Read

Insulin Resistance Syndrome- the Sensitive IRSSemantic proximity Read