Article
Huntingtin phosphorylation governs BDNF homeostasis and improves the phenotype of Mecp2 knockout mice.
EMBO molecular medicine - 7 Feb 2020
Ehinger Yann, Bruyère Julie, Panayotis Nicolas, Abada Yah-Se, Borloz Emilie, Matagne Valérie, Scaramuzzino Chiara, Vitet Hélène, Delatour Benoit, Saidi Lydia, Villard Laurent, Saudou Frédéric, Roux Jean-Christophe
Abstract excerpt
Mutations in the X-linked MECP2 gene are responsible for Rett syndrome (RTT), a severe neurological disorder for which there is no treatment. Several studies have linked the loss of MeCP2 function to alterations of brain-derived neurotrophic factor (BDNF) levels, but non-specific overexpression of BDNF only partially improves the phenotype of Mecp2-deficient mice. We and others have previously shown that...
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