Article

Huntingtin phosphorylation governs BDNF homeostasis and improves the phenotype of Mecp2 knockout mice

2019-05-20

Abstract excerpt

Mutations in the X-linked MECP2 gene are responsible for Rett syndrome (RTT), a severe neurological disorder for which there is no treatment. Several studies have linked the loss of MeCP2 function to alterations of brain-derived neurotrophic factor (BDNF) levels, but non-specific overexpression of BDNF only partially improves the phenotype of Mecp2 -deficient mice. We and others have previously shown that huntin...

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Literature Corpus work: acdd3b28-0c86-5c0b-b36c-1a307dc68983
DOI: 10.1101/643312

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