Article
Naturally occurring genetic variants in human chromogranin A (CHGA) associated with hypertension as well as hypertensive renal disease.
Cellular and molecular neurobiology - 1 Nov 2010
Chen Yuqing, Rao Fangwen, Wen Gen, Gayen Jiaur R, Zhang Kuixing, Vaingankar Sucheta M, Biswas Nilima, Mahata Manjula, Friese Ryan S, Fung Maple M, Salem Rany M, Nievergelt Caroline, Bhatnagar Vibha, Hook Vivian Y, Ziegler Michael G, Mahata Sushil K, Hamilton Bruce A, O'Connor Daniel T
Abstract excerpt
Chromogranin A (CHGA) plays a fundamental role in the biogenesis of catecholamine secretory granules. Changes in storage and release of CHGA in clinical and experimental hypertension prompted us to study whether genetic variation at the CHGA locus might contribute to alterations in autonomic function, and hence hypertension and its target organ consequences such as hypertensive renal disease (nephrosclerosis)....
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