Article
Common genetic variants in the chromogranin A promoter alter autonomic activity and blood pressure.
Kidney international - 1 Jul 2008
Chen Y, Rao F, Rodriguez-Flores J L, Mahapatra N R, Mahata M, Wen G, Salem R M, Shih P-A B, Das M, Schork N J, Ziegler M G, Hamilton B A, Mahata S K, O'Connor D T
Abstract excerpt
Chromogranin A (CHGA) is stored and released from the same secretory vesicles that contain catecholamines in chromaffin cells and noradrenergic neurons. We had previously identified common genetic variants at the CHGA locus in several human populations. Here we focus on whether inter-individual variants in the promoter region are of physiological significance. A common haplotype, CGATA (Hap-B), blunted the blood...
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