Article
Pooled-DNA sequencing identifies genomic regions of selection in Nigerian isolates of Plasmodium falciparum.
Parasites & vectors - 29 Jun 2017
Oyebola Kolapo M, Idowu Emmanuel T, Olukosi Yetunde A, Awolola Taiwo S, Amambua-Ngwa Alfred
Abstract excerpt
BACKGROUND: The burden of falciparum malaria is especially high in sub-Saharan Africa. Differences in pressure from host immunity and antimalarial drugs lead to adaptive changes responsible for high level of genetic variations within and between the parasite populations. Population-specific genetic studies to survey for genes under positive or balancing selection resulting from drug pressure or host immunity will...
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