A genome-wide map of diversity in Plasmodium falciparum.

doi:10.1038/ng1930

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Article

A genome-wide map of diversity in Plasmodium falciparum.

Nature genetics - 1 Jan 2007

Volkman Sarah K, Sabeti Pardis C, DeCaprio David, Neafsey Daniel E, Schaffner Stephen F, Milner Danny A, Daily Johanna P, Sarr Ousmane, Ndiaye Daouda, Ndir Omar, Mboup Soulyemane, Duraisingh Manoj T, Lukens Amanda, Derr Alan, Stange-Thomann Nicole, Waggoner Skye, Onofrio Robert, Ziaugra Liuda, Mauceli Evan, Gnerre Sante, Jaffe David B, Zainoun Joanne, Wiegand Roger C, Birren Bruce W, Hartl Daniel L, Galagan James E, Lander Eric S, Wirth Dyann F

Abstract excerpt

Genetic variation allows the malaria parasite Plasmodium falciparum to overcome chemotherapeutic agents, vaccines and vector control strategies and remain a leading cause of global morbidity and mortality. Here we describe an initial survey of genetic variation across the P. falciparum genome. We performed extensive sequencing of 16 geographically diverse parasites and identified 46,937 SNPs, demonstrating rich...

Topics

Africa
Animals
Asia
Central America
Chromosome Mapping
Genetic Variation
Genome, Protozoan
Genotype
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phylogeny

Plasmodium falciparum

Polymorphism, Single Nucleotide

South America

Source

Open in PubMed

Identifiers

PMID: 17159979
DOI: 10.1038/ng1930

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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