Article
Genome variation and evolution of the malaria parasite Plasmodium falciparum.
Nature genetics - 1 Jan 2007
Jeffares Daniel C, Pain Arnab, Berry Andrew, Cox Anthony V, Stalker James, Ingle Catherine E, Thomas Alan, Quail Michael A, Siebenthall Kyle, Uhlemann Anne-Catrin, Kyes Sue, Krishna Sanjeev, Newbold Chris, Dermitzakis Emmanouil T, Berriman Matthew
Abstract excerpt
Infections with the malaria parasite Plasmodium falciparum result in more than 1 million deaths each year worldwide. Deciphering the evolutionary history and genetic variation of P. falciparum is critical for understanding the evolution of drug resistance, identifying potential vaccine candidates and appreciating the effect of parasite variation on prevalence and severity of malaria in humans. Most studies of...
Topics
- Animals
- Evolution, Molecular
- Female
- Genetic Speciation
- Genetic Variation
- Genome, Protozoan
- Ghana
- Humans
- Malaria, Falciparum
- Open Reading Frames