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Article

Genome-wide analysis of selection on the malaria parasite Plasmodium falciparum in West African populations of differing infection endemicity.

Molecular biology and evolution - 1 Jun 2014

Mobegi Victor A, Duffy Craig W, Amambua-Ngwa Alfred, Loua Kovana M, Laman Eugene, Nwakanma Davis C, MacInnis Bronwyn, Aspeling-Jones Harvey, Murray Lee, Clark Taane G, Kwiatkowski Dominic P, Conway David J

Abstract excerpt

Locally varying selection on pathogens may be due to differences in drug pressure, host immunity, transmission opportunities between hosts, or the intensity of between-genotype competition within hosts. Highly recombining populations of the human malaria parasite Plasmodium falciparum throughout West Africa are closely related, as gene flow is relatively unrestricted in this endemic region, but markedly varying...

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PMID: 24644299
DOI: 10.1093/molbev/msu106
PMCID: PMC4032133

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Source receipt: pubmed, retrieved 6 Sept 2026.

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