Article
Clinical significance linked to functional defects in bone morphogenetic protein type 2 receptor, BMPR2.
BMB reports - 1 Jun 2017
Kim Myung-Jin, Park Seon Young, Chang Hae Ryung, Jung Eun Young, Munkhjargal Anudari, Lim Jong-Seok, Lee Myeong-Sok, Kim Yonghwan
Abstract excerpt
Bone morphogenetic protein type 2 receptor (BMPR2) is one of the transforming growth factor-β (TGF-β) superfamily receptors, performing diverse roles during embryonic development, vasculogenesis, and osteogenesis. Human BMPR2 consists of 1,038 amino acids, and contains functionally conserved extracellular, transmembrane, kinase, and C-terminal cytoplasmic domains. Bone morphogenetic proteins (BMPs) engage the...
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