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Article

The type I BMP receptor ACVR1/ALK2 is required for chondrogenesis during development.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Apr 2015

Rigueur Diana, Brugger Sean, Anbarchian Teni, Kim Jong Kil, Lee YooJin, Lyons Karen M

Abstract excerpt

Bone morphogenetic proteins (BMPs) are crucial regulators of chondrogenesis. BMPs transduce their signals through three type I receptors: BMPR1A, BMPR1B, and ACVR1/ALK2. Fibrodysplasia ossificans progressiva (FOP), a rare disorder characterized by progressive ossification of connective tissue, is caused by an activating mutation in Acvr1 (the gene that encodes ACVR1/ALK2). However, there are few developmental...

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Identifiers

PMID: 25413979
DOI: 10.1002/jbmr.2385
PMCID: PMC4376569

Genes

ACVR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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