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Article

Loss of BMPR2 leads to high bone mass due to increased osteoblast activity

7 Feb 2015

Abstract excerpt

Imbalances in the ratio of bone morphogenetic protein (BMP) versus activin and TGFβ signaling are increasingly associated with human diseases yet the mechanisms mediating this relationship remain unclear. The type 2 receptors ACVR2A and ACVR2B bind BMPs and activins but the type 2 receptor BMPR2 only binds BMPs, suggesting that type 2 receptor utilization might play a role in mediating the interaction of these...

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PMID: 25663702
DOI: 10.1242/jcs.156737

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Loss of BMPR2 leads to high bone mass due to increased osteoblast activityPMID 25663702Read ↗

Activin receptor type 2A (ACVR2A) functions directly in osteoblasts as a negative regulator of bone mass.Semantic proximity Read ↗

Deletion of BMP receptor type IB decreased bone mass in association with compromised osteoblastic differentiation of bone marrow mesenchymal progenitors.Semantic proximity Read ↗

Clinical significance linked to functional defects in bone morphogenetic protein type 2 receptor, BMPR2.Semantic proximity Read ↗

Over-expression of wild-type <i>ACVR1</i> in fibrodysplasia ossificans progressiva mice rescues perinatal lethality and inhibits heterotopic ossificationSemantic proximity Read ↗

The type I BMP receptor ACVR1/ALK2 is required for chondrogenesis during development.Semantic proximity Read ↗

Overexpression of Wild-Type ACVR1 in Fibrodysplasia Ossificans Progressiva Mice Rescues Perinatal Lethality and Inhibits Heterotopic Ossification.Semantic proximity Read ↗

An anti-ACVR1 antibody exacerbates heterotopic ossification by fibro/adipogenic progenitors in fibrodysplasia ossificans progressiva miceSemantic proximity Read ↗

Increased BMP-Smad signaling does not affect net bone mass in long bonesSemantic proximity Read ↗

Activin-dependent signaling in fibro/adipogenic progenitors causes fibrodysplasia ossificans progressivaSemantic proximity Read ↗

Heterotopic ossification in mice overexpressing Bmp2 in Tie2+ lineagesSemantic proximity Read ↗

ACVR1R206H receptor mutation causes fibrodysplasia ossificans progressiva by imparting responsiveness to activin A.Semantic proximity Read ↗

Type II BMP and activin receptors BMPR2 and ACVR2A share a conserved mode of growth factor recognition.Semantic proximity Read ↗

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