Article
Regulator of G protein signaling 2 is a key regulator of pancreatic β-cell mass and function.
Cell death & disease - 25 May 2017
Dong H, Zhang Y, Wang J, Kim D S, Wu H, Sjögren B, Gao W, Luttrell L, Wang H
Abstract excerpt
Pancreatic β-cell death and dysfunction contributes to the pathogenesis of both type 1 and type 2 diabetes. We aimed to examine whether the regulator of G protein signaling protein 2 (RGS2), a multifunctional inhibitor of G protein-coupled receptor (GPCR) signaling, impacts β-cell death and function. Metabolic phenotypes, β-cell secretory function, and glucose and insulin tolerance were measured in RGS2 knockout...
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