Article
Identification of an elaborate NK-specific system regulating HLA-C expression.
PLoS genetics - 1 Jan 2018
Li Hongchuan, Ivarsson Martin A, Walker-Sperling Victoria E, Subleski Jeff, Johnson Jenna K, Wright Paul W, Carrington Mary, Björkström Niklas K, McVicar Daniel W, Anderson Stephen K
Abstract excerpt
The HLA-C gene appears to have evolved in higher primates to serve as a dominant source of ligands for the KIR2D family of inhibitory MHC class I receptors. The expression of NK cell-intrinsic MHC class I has been shown to regulate the murine Ly49 family of MHC class I receptors due to the interaction of these receptors with NK cell MHC in cis. However, cis interactions have not been demonstrated for the human...
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