Niche-mediated depletion of the normal hematopoietic stem cell reservoir by Flt3-ITD-induced myeloproliferation.

doi:10.1084/jem.20161418

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Article

Niche-mediated depletion of the normal hematopoietic stem cell reservoir by Flt3-ITD-induced myeloproliferation.

The Journal of experimental medicine - 3 Jul 2017

Mead Adam J, Neo Wen Hao, Barkas Nikolaos, Matsuoka Sahoko, Giustacchini Alice, Facchini Raffaella, Thongjuea Supat, Jamieson Lauren, Booth Christopher A G, Fordham Nicholas, Di Genua Cristina, Atkinson Deborah, Chowdhury Onima, Repapi Emmanouela, Gray Nicki, Kharazi Shabnam, Clark Sally-Ann, Bouriez Tiphaine, Woll Petter, Suda Toshio, Nerlov Claus, Jacobsen Sten Eirik W

Abstract excerpt

Although previous studies suggested that the expression of FMS-like tyrosine kinase 3 (Flt3) initiates downstream of mouse hematopoietic stem cells (HSCs), FLT3 internal tandem duplications (FLT3 ITDs) have recently been suggested to intrinsically suppress HSCs. Herein, single-cell interrogation found Flt3 mRNA expression to be absent in the large majority of phenotypic HSCs, with a strong negative correlation...

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PMID: 28637883
DOI: 10.1084/jem.20161418
PMCID: PMC5502426

Genes

FLT3
TNF

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