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Article

FLT3-ITD knockin impairs hematopoietic stem cell quiescence/homeostasis, leading to myeloproliferative neoplasm.

Cell stem cell - 7 Sept 2012

Chu S Haihua, Heiser Diane, Li Li, Kaplan Ian, Collector Michael, Huso David, Sharkis Saul J, Civin Curt, Small Don

Abstract excerpt

Internal tandem duplication (ITD) mutations within the FMS-like tyrosine kinase-3 (FLT3) render the receptor constitutively active driving proliferation and survival in leukemic blasts. Expression of FLT3-ITD from the endogenous promoter in a murine knockin model results in progenitor expansion and a myeloproliferative neoplasm. In this study, we show that this expansion begins with overproliferation within a...

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Source

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Identifiers

PMID: 22958930
DOI: 10.1016/j.stem.2012.05.027
PMCID: PMC3725984

Genes

FLT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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FLT3-ITD knockin impairs hematopoietic stem cell quiescence/homeostasis, leading to myeloproliferative neoplasm.PMID 22958930Read ↗

FLT3 mutations confer enhanced proliferation and survival properties to multipotent progenitors in a murine model of chronic myelomonocytic leukemia.Semantic proximity Read ↗

Niche-mediated depletion of the normal hematopoietic stem cell reservoir by Flt3-ITD-induced myeloproliferation.Semantic proximity Read ↗

FLT3 is genetically essential for ITD-mutated leukemic stem cells but dispensable for human hematopoietic stem cellsSemantic proximity Read ↗

Knock-in of an internal tandem duplication mutation into murine FLT3 confers myeloproliferative disease in a mouse model.Semantic proximity Read ↗

Impact of gene dosage, loss of wild-type allele, and FLT3 ligand on Flt3-ITD-induced myeloproliferation.Semantic proximity Read ↗

Mutant FLT3 signaling contributes to a block in myeloid differentiationSemantic proximity Read ↗

Loss of the wild-type allele contributes to myeloid expansion and disease aggressiveness in FLT3/ITD knockin mice.Semantic proximity Read ↗

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