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Article

Knock-in of an internal tandem duplication mutation into murine FLT3 confers myeloproliferative disease in a mouse model.

Blood - 1 Apr 2008

Li Li, Piloto Obdulio, Nguyen Ho Bao, Greenberg Kathleen, Takamiya Kogo, Racke Frederick, Huso David, Small Donald

Abstract excerpt

Constitutive activation of FMS-like tyrosine kinase 3 (FLT3) by internal tandem duplication (ITD) mutations is one of the most common molecular alterations known in acute myeloid leukemia (AML). To investigate the role FLT3/ITD mutations play in the development of leukemia, we generated a FLT3/ITD knock-in mouse model by inserting an ITD mutation into the juxtamembrane domain of murine Flt3. FLT3wt/ITD mice...

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Source

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Identifiers

PMID: 18245664
DOI: 10.1182/blood-2007-08-109942
PMCID: PMC2275036

Genes

FLT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Knock-in of an internal tandem duplication mutation into murine FLT3 confers myeloproliferative disease in a mouse model.PMID 18245664Read ↗

FLT3 internal tandem duplication mutations associated with human acute myeloid leukemias induce myeloproliferative disease in a murine bone marrow transplant model.Semantic proximity Read ↗

FLT3 internal tandem duplication mutations induce myeloproliferative or lymphoid disease in a transgenic mouse model.Semantic proximity Read ↗

Dnmt3a deletion cooperates with the Flt3/ITD mutation to drive leukemogenesis in a murine model.Semantic proximity Read ↗

Cre recombinase expression cooperates with homozygous FLT3 internal tandem duplication knockin mouse model to induce acute myeloid leukemia.Semantic proximity Read ↗

Impact of gene dosage, loss of wild-type allele, and FLT3 ligand on Flt3-ITD-induced myeloproliferation.Semantic proximity Read ↗

FLT3-ITD and tyrosine kinase domain mutants induce 2 distinct phenotypes in a murine bone marrow transplantation model.Semantic proximity Read ↗

FLT3 mutations confer enhanced proliferation and survival properties to multipotent progenitors in a murine model of chronic myelomonocytic leukemia.Semantic proximity Read ↗

Loss of the wild-type allele contributes to myeloid expansion and disease aggressiveness in FLT3/ITD knockin mice.Semantic proximity Read ↗

Mutant FLT3 signaling contributes to a block in myeloid differentiationSemantic proximity Read ↗

Mll partial tandem duplication and Flt3 internal tandem duplication in a double knock-in mouse recapitulates features of counterpart human acute myeloid leukemiasSemantic proximity Read ↗

Molecular and cellular effects of oncogene cooperation in a genetically accurate AML mouse model.Semantic proximity Read ↗

FLT3-ITD knockin impairs hematopoietic stem cell quiescence/homeostasis, leading to myeloproliferative neoplasm.Semantic proximity Read ↗

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