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Article

The mesenchymal niche in MDS

23 Jan 2019

Abstract excerpt

Myelodysplastic syndrome (MDS) is characterized by bone marrow failure and a strong propensity for leukemic evolution. Somatic mutations are critical early drivers of the disorder, but the factors enabling the emergence, selection, and subsequent leukemic evolution of these "leukemia-poised" clones remain incompletely understood. Emerging data point at the mesenchymal niche as a critical contributor to disease...

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Identifiers

PMID: 30670448
DOI: 10.1182/blood-2018-10-844639

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