Article

Loss of HSC stemness identity is associated with exhaustion and hyporesponsiveness in GATA2 deficiency syndrome

2023-08-07

Abstract excerpt

Germline GATA2 mutations lead to a syndrome involving both immunodeficiency and myeloid malignancies. Since GATA2 is a key player in hematopoietic initiation and development, we specify the impact of these germline mutations on hematopoietic homeostasis by generated a knock-in mouse model expressing the recurrent Gata2 R396Q missense mutation. These mice exhibit a hematopoietic stem and progenitor cell (HSPC) co...

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Literature Corpus work: f8f97934-dcb2-52bb-8746-cbb0402b09c2
DOI: 10.1101/2023.08.07.551811

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Loss of HSC stemness identity is associated with exhaustion and hyporesponsiveness in GATA2 deficiency syndromeDOI 10.1101/2023.08.07.551811Read

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