Article

FLT3 is genetically essential for ITD-mutated leukemic stem cells but dispensable for human hematopoietic stem cells

2024-07-02

Abstract excerpt

<h4>ABSTRACT</h4> Leukemic stem cells (LSCs) fuel acute myeloid leukemia (AML) growth and relapse, but therapies tailored towards eradicating LSCs without harming healthy hematopoietic stem cells (HSCs) are lacking. FLT3 is considered an important therapeutic target due to frequent mutation in AML and association with relapse. However, there has been limited clinical success with FLT3 targeting, suggesting either...

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Literature Corpus work: 1a024566-7d2a-5714-8415-01cd69e3c83d
DOI: 10.1101/2024.06.30.601363

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