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Article

Tumor necrosis factor restricts hematopoietic stem cell activity in mice: involvement of two distinct receptors.

The Journal of experimental medicine - 1 Aug 2011

Pronk Cornelis J H, Veiby Ole Petter, Bryder David, Jacobsen Sten Eirik W

Abstract excerpt

Whereas maintenance of hematopoietic stem cells (HSCs) is a requisite for life, uncontrolled expansion of HSCs might enhance the propensity for leukemic transformation. Accordingly, HSC numbers are tightly regulated. The identification of physical cellular HSC niches has underscored the importance of extrinsic regulators of HSC homeostasis. However, whereas extrinsic positive regulators of HSCs have been...

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Source

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Identifiers

PMID: 21768269
DOI: 10.1084/jem.20110752
PMCID: PMC3149225

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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