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Article

FLT3 mutations confer enhanced proliferation and survival properties to multipotent progenitors in a murine model of chronic myelomonocytic leukemia.

Cancer cell - 1 Oct 2007

Lee Benjamin H, Tothova Zuzana, Levine Ross L, Anderson Kristina, Buza-Vidas Natalija, Cullen Dana E, McDowell Elizabeth P, Adelsperger Jennifer, Fröhling Stefan, Huntly Brian J P, Beran Miloslav, Jacobsen Sten Eirik, Gilliland D Gary

Abstract excerpt

Despite their known transforming properties, the effects of leukemogenic FLT3-ITD mutations on hematopoietic stem and multipotent progenitor cells and on hematopoietic differentiation are not well understood. We report a mouse model harboring an ITD in the murine Flt3 locus that develops myeloproliferative disease resembling CMML and further identified FLT3-ITD mutations in a subset of human CMML. These findings...

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Source

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Identifiers

PMID: 17936561
DOI: 10.1016/j.ccr.2007.08.031
PMCID: PMC2104473

Genes

FLT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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FLT3 mutations confer enhanced proliferation and survival properties to multipotent progenitors in a murine model of chronic myelomonocytic leukemia.PMID 17936561Read ↗

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