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Article

Impact of gene dosage, loss of wild-type allele, and FLT3 ligand on Flt3-ITD-induced myeloproliferation.

Blood - 29 Sept 2011

Kharazi Shabnam, Mead Adam J, Mansour Anna, Hultquist Anne, Böiers Charlotta, Luc Sidinh, Buza-Vidas Natalija, Ma Zhi, Ferry Helen, Atkinson Debbie, Reckzeh Kristian, Masson Kristina, Cammenga Jörg, Rönnstrand Lars, Arai Fumio, Suda Toshio, Nerlov Claus, Sitnicka Ewa, Jacobsen Sten Eirik W

Abstract excerpt

Acquisition of homozygous activating growth factor receptor mutations might accelerate cancer progression through a simple gene-dosage effect. Internal tandem duplications (ITDs) of FLT3 occur in approximately 25% cases of acute myeloid leukemia and induce ligand-independent constitutive signaling. Homozygous FLT3-ITDs confer an adverse prognosis and are frequently detected at relapse. Using a mouse knockin model...

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Source

Identifiers

PMID: 21813452
DOI: 10.1182/blood-2010-06-289207

Genes

FLT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Impact of gene dosage, loss of wild-type allele, and FLT3 ligand on Flt3-ITD-induced myeloproliferation.PMID 21813452Read ↗

Loss of the wild-type allele contributes to myeloid expansion and disease aggressiveness in FLT3/ITD knockin mice.Semantic proximity Read ↗

Knock-in of an internal tandem duplication mutation into murine FLT3 confers myeloproliferative disease in a mouse model.Semantic proximity Read ↗

Cre recombinase expression cooperates with homozygous FLT3 internal tandem duplication knockin mouse model to induce acute myeloid leukemia.Semantic proximity Read ↗

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FLT3-ITD knockin impairs hematopoietic stem cell quiescence/homeostasis, leading to myeloproliferative neoplasm.Semantic proximity Read ↗

Mll partial tandem duplication and Flt3 internal tandem duplication in a double knock-in mouse recapitulates features of counterpart human acute myeloid leukemiasSemantic proximity Read ↗

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Dnmt3a deletion cooperates with the Flt3/ITD mutation to drive leukemogenesis in a murine model.Semantic proximity Read ↗

Absence of the wild-type allele predicts poor prognosis in adult de novo acute myeloid leukemia with normal cytogenetics and the internal tandem duplication of FLT3: a cancer and leukemia group B study.Semantic proximity Read ↗

FLT3 internal tandem duplication mutations associated with human acute myeloid leukemias induce myeloproliferative disease in a murine bone marrow transplant model.Semantic proximity Read ↗

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