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Article

Microenvironmental CXCL12 deletion enhances Flt3-ITD acute myeloid leukemia stem cell response to therapy by reducing p38 MAPK signaling.

Leukemia - 1 Mar 2023

Anderson Nicholas R, Sheth Vipul, Li Hui, Harris Mason W, Qiu Shaowei, Crossman David K, Kumar Harish, Agarwal Puneet, Nagasawa Takashi, Paterson Andrew J, Welner Robert S, Bhatia Ravi

Abstract excerpt

Fms-like tyrosine kinase 3 (Flt3) tyrosine kinase inhibitors (Flt3-TKI) have improved outcomes for patients with Flt3-mutated acute myeloid leukemia (AML) but are limited by resistance and relapse, indicating persistence of leukemia stem cells (LSC). Here utilizing a Flt3-internal tandem duplication (Flt3-ITD) and Tet2-deleted AML genetic mouse model we determined that FLT3-ITD AML LSC were enriched within the...

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Share to Chemokine CXCL12
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to MAP Kinase Signaling System

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Identifiers

PMID: 36550214
DOI: 10.1038/s41375-022-01798-5
PMCID: PMC10750268

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