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Article

Phosphorylation at serine 31 targets tyrosine hydroxylase to vesicles for transport along microtubules.

The Journal of biological chemistry - 25 Aug 2017

Jorge-Finnigan Ana, Kleppe Rune, Jung-Kc Kunwar, Ying Ming, Marie Michael, Rios-Mondragon Ivan, Salvatore Michael F, Saraste Jaakko, Martinez Aurora

Abstract excerpt

Tyrosine hydroxylase (TH) catalyzes the conversion of l-tyrosine into l-DOPA, which is the rate-limiting step in the synthesis of catecholamines, such as dopamine, in dopaminergergic neurons. Low dopamine levels and death of the dopaminergic neurons are hallmarks of Parkinson's disease (PD), where α-synuclein is also a key player. TH is highly regulated, notably by phosphorylation of several Ser/Thr residues in...

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Identifiers

PMID: 28637871
DOI: 10.1074/jbc.M116.762344
PMCID: PMC5572922

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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