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Article

Active tyrosine hydroxylase mutant in genome-edited mice leads to lower enzyme levels in the striatum.

Biochemical and biophysical research communications - 18 Jan 2026

Sazali Aina Syazwina Binti, Natsume Rie, Sakimura Kenji, Abe Manabu, Ichinose Hiroshi

Abstract excerpt

Tyrosine hydroxylase (TH) is the rate-limiting enzyme for catecholamine biosynthesis and dysregulation in the catecholamine metabolism is implicated in various kinds of disorders including neuropsychiatric disorders and cardiovascular disorders. The TH activity is majorly regulated by phosphorylation of its 40Ser residue, which is located in the intrinsically disordered N-terminal region of the enzyme. This...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41411910
DOI: 10.1016/j.bbrc.2025.153129

Genes

TH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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