Article
Identification of a novel phosphorylation site in ataxin-1.
Biochimica et biophysica acta - 15 May 2005
Vierra-Green Cynthia A, Orr Harry T, Zoghbi Huda Y, Ferrington Deborah A
Abstract excerpt
Spinocerebellar ataxia type 1 (SCA1) is an autosomal dominant neurodegenerative disease resulting from an expanded CAG repeat in the SCA1 gene that leads to an expanded polyglutamine tract in the gene product. Previous studies have demonstrated that serine at site 776 is phosphorylated [E.S. Emiamian, M.D. Kaytor, L.A. Duvick, T. Zu, S.K. Tousey, H.Y. Zoghbi, H.B. Clark, H.T. Orr, Serine 776 of ataxin-1 is...
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